Tyne Daly, the Tony- and Emmy-winning actress, is withdrawing from a starring role in the first Broadway revival of “Doubt: A Parable,” citing health issues.

Daly was set to star in the production of John Patrick Shanley’s Pulitzer Prize-winning 2004 play about a sexual assault accusation against a Catholic priest. She will be replaced by Amy Ryan, who will begin performances Feb. 13.

Roundabout Theater Company, the nonprofit producing the revival, announced the cast change on Tuesday, saying in a news release, “Ms. Daly was unexpectedly hospitalized on Friday and unfortunately needs to withdraw from the production while she receives medical care; she is thankfully expected to make a full recovery.” The organization did not provide further details.

The “Doubt” revival, also starring Liev Schreiber, was to begin previews last Friday, but that first performance was canceled by Roundabout. The production then began performances on Saturday, with the understudy Isabel Keating going on in Daly’s stead; Keating has been performing the lead role since then, and will continue to do so through Sunday.

Daly was to play Sister Aloysius Beauvier, a nun who serves as the principal at a Catholic school and who suspects the parish priest, Father Brendan Flynn, of misconduct. Schreiber is playing the priest. In 2008, the play was adapted into a film starring Meryl Streep and Philip Seymour Hoffman; it was also adapted into an opera.

Daly, 77, has worked steadily onstage and screen. She has performed in seven previous Broadway shows, winning a Tony Award in 1990 for starring in a revival of “Gypsy,” and earning two more nominations since. She has also won six Emmy Awards, for the television shows “Cagney & Lacey,” “Christy” and “Judging Amy.”

Ryan, 55, has performed in five previous Broadway shows, and was nominated twice for Tony Awards in Roundabout revivals. Her last appearance on Broadway was nearly two decades ago, when she was featured in a revival of “A Streetcar Named Desire.” Since that time she has worked primarily on film and television, earning an Oscar nomination for her work in “Gone Baby Gone.”

The “Doubt” revival, directed by Scott Ellis, will now open March 7, one week later than initially planned. The production, which is scheduled to run until April 14, also features Quincy Tyler Bernstine and Zoe Kazan.